|
rs11674595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results reveal the significant association between SNPs (rs11674595 and rs2072472) in the IL1R2 and EC risk in the Chinese Han population.
|
31744444 |
2019 |
|
rs2072472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results reveal the significant association between SNPs (rs11674595 and rs2072472) in the IL1R2 and EC risk in the Chinese Han population.
|
31744444 |
2019 |
|
rs1052133
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis on hOGG1 Ser326Cys polymorphism and the risk of EC suggests there is no statistically significant association between the two.
|
31700874 |
2019 |
|
rs115510139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analysis was performed by gender, age, alcohol drinking, BMI, TNM stage and lymph node metastasis, the results showed that rs7436, rs115510139 and rs6720283 were significantly associated with the risk of EC in different groups (all p < 0.05).
|
31425922 |
2019 |
|
rs6720283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analysis was performed by gender, age, alcohol drinking, BMI, TNM stage and lymph node metastasis, the results showed that rs7436, rs115510139 and rs6720283 were significantly associated with the risk of EC in different groups (all p < 0.05).
|
31425922 |
2019 |
|
rs7436
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analysis was performed by gender, age, alcohol drinking, BMI, TNM stage and lymph node metastasis, the results showed that rs7436, rs115510139 and rs6720283 were significantly associated with the risk of EC in different groups (all p < 0.05).
|
31425922 |
2019 |
|
rs4646903
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The <i>CYP1A1</i> rs4646903 and <i>CYP2E1</i> rs2031920 polymorphisms were risk factors of GCC or EC, and the <i>GSTM1</i> null genotype may serve a protective role against EC.
|
31423187 |
2019 |
|
rs2031920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>CYP1A1</i> rs4646903 and <i>CYP2E1</i> rs2031920 polymorphisms were risk factors of GCC or EC, and the <i>GSTM1</i> null genotype may serve a protective role against EC.
|
31423187 |
2019 |
|
rs3738894
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The gene-Environment interaction between rs3738894 and smoking history was associated with the risk of esophageal cancer.
|
31269493 |
2020 |
|
rs1884444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
IL23R rs1884444 allele G decreased the risk of esophageal cancer under allele, genotype, and additive models (allele model: OR = 0.82, 95% CI: 0.68-0.98, P = .032; genotype model: OR = 0.65, 95% CI: 0.44-0.97, P = .035; additive model: OR = 0.82, 95% CI: 0.68-0.98, P = .031).
|
31197899 |
2019 |
|
rs6682925
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic regression analysis was used to evaluate the odd ratios (ORs) and 95% confidence intervals (CIs) of rs1884444 and rs6682925 with susceptibility of esophageal cancer.A total of 30 articles are eligible.
|
31197899 |
2019 |
|
rs315919
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provided the first evidence that IL1RN rs3181052, rs452204, and rs315919 are correlated with a decreased risk of esophageal cancer in a Northwest Han Chinese population.
|
30995661 |
2019 |
|
rs3181052
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In stratified analyses </span>by age >55 years, rs3181052 reduced the risk of esophageal cancer in the dominant and overdominant models.
|
30995661 |
2019 |
|
rs452204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provided the first evidence that IL1RN rs3181052, rs452204, and rs315919 are correlated with a decreased risk of esophageal cancer in a Northwest Han Chinese population.
|
30995661 |
2019 |
|
rs2274223
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs3765524
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs10509670
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs671
|
|
|
0.880 |
GeneticVariation |
BEFREE |
However, the results remain inconclusive.We conducted a comprehensive meta-analysis including 63 articles with 66 studies containing 25,682 cases and 47,455 controls retrieved by searching PubMed and Embase electronic databases up to March 5, 2018.Pooled results indicated that ALDH2 gene rs671 polymorphism was significantly associated with the overall cancer risk in Asians (homozygous model: odds ratio [OR] = 0.85, 95% confidence interval [CI] = 0.72-0.99, P = .042; heterozygous model: OR = 1.32, 95% CI = 1.14-1.52, P < .001; recessive model: OR = 0.73, 95% CI = 0.60-0.88, P = .001; dominant model: OR = 1.32, 95% CI = 1.16-1.51, P < .001; and allele comparison model: OR = 1.11, 95% CI = 1.03-1.19, P = .004), especially in esophageal cancer and among the Chinese and the Japanese.Our results suggest that ALDH2 rs671 polymorphism is associated with the overall cancer risk in Asians.
|
30921184 |
2019 |
|
rs1800629
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Background</b>: TNF-α-308G/A (rs1800629) polymorphism has been previously implicated in the susceptibility to esophageal cancer, but results of these studies remained controversial or ambiguous.
|
30854115 |
2019 |
|
rs3212986
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, our results indicate that the <i>ERCC1</i> rs3212986 and the <i>ERCC2/XPD</i> rs1799793 could be used as surrogate markers for a better stratification of EC patients with advanced resectable tumor.
|
30847299 |
2019 |
|
rs1799793
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our results indicate that the <i>ERCC1</i> rs3212986 and the <i>ERCC2/XPD</i> rs1799793 could be used as surrogate markers for a better stratification of EC patients with advanced resectable tumor.
|
30847299 |
2019 |
|
rs3787016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs3787016 polymorphism, in polymerase II polypeptide E (POLR2E), was previously identified as being associated with the risk for prostate cancer, esophageal cancer, breast cancer, papillary thyroid carcinoma and liver cancer, suggesting that rs3787016 may server as a common genetic factor to affect individual susceptibility to cancer.
|
30846411 |
2019 |
|
rs2274223
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In additional, five variants on five genes were rated as strong cumulative epidemiological evidence for a nominally significant association with EC and ESCC risk, including CYP1A1 rs1048943, EGF rs444903, HOTAIR rs920778, MMP2 rs243865, and PLCE1 rs2274223, 10 variants were rated as moderate, and 18 variants were rated as weak.
|
30793520 |
2019 |
|
rs1048943
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In additional, five variants on five genes were rated as strong cumulative epidemiological evidence for a nominally significant association with EC and ESCC risk, including CYP1A1 rs1048943, EGF rs444903, HOTAIR rs920778, MMP2 rs243865, and PLCE1 rs2274223, 10 variants were rated as moderate, and 18 variants were rated as weak.
|
30793520 |
2019 |
|
rs2274223
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72-0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12-1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11-1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74-0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10-1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78-0.98) in overall population.
|
30784231 |
2019 |